Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30075883 | 0.92 | ATF4 (0.57) | ATF4MAOB | |
| SCHEMBL20974206 | 0.92 | ATF4 (0.57) | ATF4MAOB | |
| SCHEMBL19569276 | 0.92 | HTT (0.43) | ATF4MAOBHTTMAOA | |
| SCHEMBL19569425 | 0.88 | ATF4 (0.51) | ATF4 | |
| SCHEMBL19569471 | 0.87 | ATF4 (0.48) | ATF4MAOBHTTMAOA | |
| SCHEMBL22669532 | 0.87 | MAOB (0.42) | ATF4MAOBHTTMAOA | |
| SCHEMBL19569436 | 0.86 | ATF4 (0.56) | ATF4 | |
| SCHEMBL19569441 | 0.85 | ATF4 (0.50) | ATF4 | |
| SCHEMBL19569585 | 0.84 | ATF4 (0.61) | ATF4MAOBHTT | |
| SCHEMBL19569462 | 0.84 | ATF4 (0.47) | ATF4MAOBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |