Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 16/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28580886 | 0.86 | ATF4 (0.63) | ATF4LMNA | |
| SCHEMBL28580887 | 0.86 | ATF4 (0.63) | ATF4LMNA | |
| SCHEMBL22362367 | 0.86 | ATF4 (0.71) | ATF4LMNARAB9A | |
| SCHEMBL22362323 | 0.86 | ATF4 (0.71) | ATF4LMNARAB9A | |
| SCHEMBL23455910 | 0.84 | ATF4 (0.65) | ATF4LMNA | |
| SCHEMBL23455912 | 0.84 | ATF4 (0.65) | ATF4LMNA | |
| SCHEMBL16082976 | 0.83 | ATF4 (0.78) | ATF4LMNANPC1RAB9A | |
| SCHEMBL20974292 | 0.82 | ATF4 (0.67) | ATF4 | |
| SCHEMBL19569586 | 0.82 | ATF4 (0.56) | ATF4 | |
| SCHEMBL22362298 | 0.82 | ATF4 (0.66) | ATF4LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |