Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20999374 | 1.00 | NPC1 (0.52) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL22669314 | 1.00 | NPC1 (0.52) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL15707913 | 1.00 | NPC1 (0.52) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL18097667 | 0.97 | — | — | |
| SCHEMBL21810782 | 0.92 | — | — | |
| SCHEMBL14795233 | 0.86 | — | — | |
| SCHEMBL4516905 | 0.83 | NPC1 (0.47) | NPC1NAAA | |
| SCHEMBL10357183 | 0.83 | NPC1 (0.61) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL6377426 | 0.83 | NPC1 (0.61) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL6376493 | 0.83 | NPC1 (0.61) | NPC1NAAACA1CA2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |