⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21810782 | 0.88 | — | — | |
| SCHEMBL18097667 | 0.88 | — | — | |
| SCHEMBL22669314 | 0.86 | NPC1 (0.52) | — | |
| SCHEMBL20999374 | 0.86 | NPC1 (0.52) | — | |
| SCHEMBL15707913 | 0.86 | NPC1 (0.52) | — | |
| SCHEMBL19569733 | 0.86 | NPC1 (0.52) | — | |
| SCHEMBL15577598 | 0.82 | — | — | |
| SCHEMBL8077573 | 0.82 | NPC1 (0.34) | — | |
| Bromide SCHEMBL11399424 | 0.80 | SLC6A2 (0.35) | — | |
| SCHEMBL6378425 | 0.79 | NPC1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661009-B | Anti- enteric virus71 thiadiazolidine derivative | 江苏康缘药业股份有限公司 | 2019-11-26 | — | — | CN | disclosed |
| CN-110305109-A | The indazole of new substituted, preparation method, comprising its pharmaceutical preparation and its be used to prepare the purposes of drug | 拜耳医药股份有限公司 | 2019-10-08 | — | — | CN | disclosed |
| CN-109152771-A | The indazole that 2- replaces is used to treat and prevent the purposes of autoimmune disease | 拜耳医药股份有限公司 | 2019-01-04 | — | — | CN | disclosed |
| EP-2573090-B1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-12-10 | — | — | EP | disclosed |
| US-8563547-B2 | (6,7-dihydro-2-nitro-5H-imidazol[2,1-b][1,3]oxazin-6-yl) amide compounds, preparation methods and uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2013-10-22 | — | — | US | disclosed |
| US-20130143864-A1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | NANJING CHANGAO PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2013-06-06 | — | — | US | disclosed |
| EP-2573090-A1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd (CN) | 2013-03-27 | — | — | EP | disclosed |