Almotriptan

Almotriptan

SCHEMBL1957

CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HTR1BHTR1DHTR1F

The experimentally established mechanism targets of Almotriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D known ✓ P28221 4/20 0.65
HTR1B known ✓ P28222 4/20 0.65
HTR1F known ✓ P30939 1/20 0.65
HTR1A P08908 7/20 1.00
HTR2A P28223 4/20 1.00
HTR2B P41595 2/20 1.00
LMNA P02545 1/20 1.00
ADRA2B P18089 1/20 1.00
KCNH2 Q12809 1/20 1.00
HTR5A P47898 11/20 0.65
HTR7 P34969 2/20 0.65
HTR2C P28335 2/20 0.65
HTR1E P28566 1/20 0.65
HTR3A P46098 1/20 0.65
SLC47A1 Q96FL8 1/20 0.65
KMT2A Q03164 1/20 0.53
ADRA1A P35348 1/20 0.53
HTR6 P50406 1/20 0.53
MPO P05164 1/20 0.51
SLC6A4 P31645 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Almotriptan SCHEMBL29396422 1.00 HTR1A (1.00) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL3273179 1.00 HTR1A (1.00) HTR1AHTR2AHTR2BLMNAADRA2B
SCHEMBL1437 0.99 HTR1A (0.98) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL2166 0.99 HTR1A (0.98) HTR1AHTR2AHTR2BLMNAADRA2B
Hydrochloric Acid SCHEMBL2312 0.98 HTR1A (0.96) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL5042399 0.98 HTR1A (0.96) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL1774275 0.95 HTR1A (0.90) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL2761861 0.93 HTR1A (0.86) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL6444414 0.93 HTR1A (0.86) HTR1AHTR2AHTR2BLMNAADRA2B
Almotriptan SCHEMBL221132 0.92 HTR1A (0.85) HTR1AHTR2AHTR2BLMNAADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8445 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075410-A Dry powder composition for intranasal delivery 2026-05-26 CN claimed
US-20260131089-A1 DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY APTARGROUP, INC. (US) 2026-05-14 US claimed
EP-4740962-A1 PHARMACEUTICAL COMPOSITION, FORMULATION CONTAINING PHARMACEUTICAL COMPOSITION, KIT CONTAINING PHARMACEUTICAL COMPOSITION, PREPARATION METHOD FOR PHARMACEUTICAL COMPOSITION, AND USE OF PHARMACEUTICAL COMPOSITION Shanghai WD Pharmaceutical Co., Ltd (CN) 2026-05-13 EP claimed
EP-4734974-A1 CANNABINOID COMPOSITION FOR USE IN THE TREATMENT OF PAIN AND/OR INFLAMMATION Mabewo Phytopharm AG (CH) 2026-05-06 EP claimed
WO-2026090164-A1 COMPOSITIONS COMPRISING ELISMETREP AND A SECOND THERAPEUTIC AGENT FOR TREATING OR PREVENTING MIGRAINE OR PAIN KALLYOPE, INC. (US) 2026-04-30 WO claimed
EP-4731194-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP Technologies, Inc. (US) 2026-04-29 EP claimed
EP-4698530-A1 NK3 MODULATORS AND USES THEREOF Kallyope, Inc. (US) 2026-02-25 EP claimed
US-20260027337-A1 TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS MORNINGSIDE VENTURE INVESTMENTS LTD (MC) 2026-01-29 US claimed
EP-4681714-A2 METHODS OF TREATING THE SYMPTOMS OF AUTISM SPECTRUM DISORDER MapLight Therapeutics, Inc. (US) 2026-01-21 EP claimed
US-12515030-B2 Transdermal drug delivery devices and methods MORNINGSIDE VENTURE INVESTMENTS LIMITED (MC) 2026-01-06 US claimed
US-6060499-A Anti-migraine methods and compositions using 5-HT agonists with long-acting NSAIDs POZEN, INC. (US) 2000-05-09 US claimed
JP-2000505090-A 2000-04-25 JP claimed
WO-2000006161-A1 PREVENTION OF MIGRAINE RECURRENCE PFIZER LIMITED (GB) 2000-02-10 WO claimed
EP-0969842-A1 PHARMACEUTICAL COMPOSITION R.P. Scherer Limited (GB) 2000-01-12 EP claimed
WO-1999064044-A1 NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS ADVANCED MEDICINE, INC. (US) 1999-12-16 WO claimed
CN-1225018-A Inclusion complex containing indole selective serotonin agonist FARMARC NEDERLAND BV (NL) 1999-08-04 CN claimed
EP-0605697-B1 INDOL DERIVATIVES FOR THE TREATMENT OF MIGRAINE ALMIRALL PRODESFARMA SA (ES) 1999-03-03 EP claimed
WO-1998042344-A1 PHARMACEUTICAL COMPOSITION R. P. SCHERER LIMITED (GB) 1998-10-01 WO claimed
WO-1998002186-A1 INCLUSION COMPLEX CONTAINING INDOLE SELECTIVE SEROTONIN AGONIST FARMARC NEDERLAND B.V. (NL) 1998-01-22 WO claimed
US-5565447-A ALMOTRIPTAN MALATE; TREATING HEADACHES, MOVEMENT DISORDERS, DEPRESSION, ANXIETY LABORATORIOS ALMIRALL S.A. (ES) 1996-10-15 US claimed