Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 11/20 | 0.53 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 9/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958974 | 0.95 | BCL2 (0.58) | BCL2BAK1BCL2L1HTR7CYP1A2 | |
| SCHEMBL2826626 | 0.85 | BCL2 (0.60) | BCL2BAK1BCL2L1HTR7 | |
| SCHEMBL1960149 | 0.85 | BCL2 (0.58) | BCL2BAK1BCL2L1HTR7 | |
| SCHEMBL1743551 | 0.85 | HTR7 (0.63) | BCL2BAK1BCL2L1HTR7CYP1A2 | |
| SCHEMBL1959679 | 0.83 | HTR7 (0.58) | BCL2BAK1BCL2L1HTR7 | |
| SCHEMBL1958753 | 0.83 | BCL2 (0.58) | BCL2BAK1BCL2L1HTR7CYP1A2 | |
| SCHEMBL1955301 | 0.82 | BCL2 (0.62) | BCL2BAK1BCL2L1 | |
| SCHEMBL1742388 | 0.82 | BCL2 (0.65) | BCL2BCL2L1 | |
| SCHEMBL1743570 | 0.82 | BCL2 (0.56) | BCL2BAK1BCL2L1HTR7 | |
| SCHEMBL1957002 | 0.81 | BCL2 (0.54) | BCL2BAK1BCL2L1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507211-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| EP-2376197-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2011068560-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |
| WO-2010065824-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |