Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 18/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577455 | 0.93 | ATF4 (0.43) | ATF4PTGESHTT | |
| SCHEMBL24323366 | 0.93 | ATF4 (0.43) | ATF4PTGESHTT | |
| SCHEMBL24323479 | 0.92 | ATF4 (0.44) | ATF4 | |
| SCHEMBL24322972 | 0.92 | ATF4 (0.44) | ATF4 | |
| SCHEMBL24323279 | 0.90 | ATF4 (0.47) | ATF4SMN1; SMN2 | |
| SCHEMBL24323038 | 0.89 | ATF4 (0.48) | ATF4 | |
| SCHEMBL24323329 | 0.89 | ATF4 (0.46) | ATF4 | |
| SCHEMBL24324152 | 0.88 | ATF4 (0.45) | ATF4 | |
| SCHEMBL24323037 | 0.88 | ATF4 (0.45) | ATF4LMNA | |
| SCHEMBL24324501 | 0.88 | ATF4 (0.42) | ATF4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193041-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |