SCHEMBL19578043

SCHEMBL19578043

CC(O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(CCC(F)(F)F)c2=O)nn1-c1ncccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 20/20 0.58
AVPR1A P37288 20/20 0.58
SLC6A2 P23975 1/20 0.58
OXTR P30559 1/20 0.58
OPRK1 P41145 1/20 0.58
AVPR1B P47901 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19577925 0.93 AVPR2 (0.57) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19568109 0.93 AVPR2 (0.52) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577899 0.92 AVPR2 (0.57) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577692 0.90 AVPR2 (0.55) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19578004 0.90 AVPR2 (0.49) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577978 0.89 AVPR2 (0.74) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL20974704 0.89 AVPR2 (0.74) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19578044 0.89 AVPR2 (0.74) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19575134 0.89 AVPR2 (0.64) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19578037 0.88 AVPR2 (0.59) AVPR2AVPR1ASLC6A2OXTROPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017191114-A1 HYDROXYALKYL-SUBSTITUTED HETEROARYLTRIAZOLE DERIVATIVES AND USES THEREOF BAYER AKTIENGESELLSCHAFT (DE) 2017-11-09 WO disclosed