Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000400 | 0.95 | SLC34A2 (0.48) | SLC34A2KLKB1KLK1KDM1AHDAC1 | |
| SCHEMBL19579947 | 0.94 | SLC34A2 (0.53) | SLC34A2KDM1AHDAC1ROCK2ROCK1 | |
| SCHEMBL19580004 | 0.90 | SLC34A2 (0.52) | SLC34A2KDM1AHDAC1ROCK2ROCK1 | |
| SCHEMBL19579978 | 0.89 | SLC34A2 (0.51) | SLC34A2KDM1AHDAC1ROCK2ROCK1 | |
| SCHEMBL19579973 | 0.89 | SLC34A2 (0.53) | SLC34A2KDM1AHDAC1ROCK2ROCK1 | |
| SCHEMBL19580001 | 0.87 | SLC34A2 (0.52) | SLC34A2KDM1AHDAC1ROCK2ROCK1 | |
| SCHEMBL19579946 | 0.87 | SLC34A2 (0.51) | SLC34A2KDM1AHDAC1LMNA | |
| SCHEMBL19579952 | 0.87 | SLC34A2 (0.49) | SLC34A2KDM1AHDAC1ROCK2ROCK1 | |
| SCHEMBL45535 | 0.87 | SLC34A2 (0.64) | SLC34A2ROCK2ROCK1LMNAKDM4E | |
| SCHEMBL46817 | 0.87 | KDM1A (0.51) | SLC34A2KDM1AHDAC1MAPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | claimed |