Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 7/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959542 | 0.90 | BCL2 (0.50) | BCL2BCL2L1 | |
| SCHEMBL1958753 | 0.83 | BCL2 (0.58) | BCL2BCL2L1BAK1HTR7 | |
| SCHEMBL2481903 | 0.83 | BCL2 (0.55) | BCL2BCL2L1POLB | |
| SCHEMBL1742850 | 0.82 | BCL2 (0.63) | BCL2BCL2L1 | |
| SCHEMBL1958172 | 0.81 | BCL2 (0.55) | BCL2BCL2L1BAK1HTR7 | |
| SCHEMBL1957092 | 0.79 | BCL2 (0.59) | BCL2 | |
| SCHEMBL1954789 | 0.77 | BCL2 (0.58) | BCL2BCL2L1 | |
| SCHEMBL1959679 | 0.76 | HTR7 (0.58) | BCL2BCL2L1BAK1HTR7 | |
| SCHEMBL1957245 | 0.75 | BCL2 (0.60) | BCL2BCL2L1DRD2DRD4DRD3 | |
| SCHEMBL1958640 | 0.75 | BCL2 (0.57) | BCL2BCL2L1BAK1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507211-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068560-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |