Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1961025 | 0.93 | ALDH1A1 (0.38) | ALDH1A1MAPK1FDFT1HTTTDP1 | |
| SCHEMBL27147171 | 0.75 | ALDH1A1 (0.40) | ALDH1A1MAPK1GAAHTTTDP1 | |
| SCHEMBL2524424 | 0.71 | PLK4 (0.43) | ALDH1A1MAPK1GAAKDM4ECA12 | |
| SCHEMBL2521094 | 0.69 | RPS6KA3 (0.43) | ALDH1A1MAPK1HTTTDP1HPGD | |
| SCHEMBL30782331 | 0.68 | MCHR1 (0.39) | ALDH1A1MAPK1FDFT1CA12CA1 | |
| SCHEMBL8486452 | 0.67 | KCNK3 (0.57) | ALDH1A1TDP1HPGDNPSR1KDM4E | |
| SCHEMBL2518050 | 0.65 | MEN1 (0.49) | ALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL18932193 | 0.65 | CHRNA7 (0.39) | ALDH1A1MAPK1HPGDNPSR1KDM4E | |
| SCHEMBL14811913 | 0.64 | KCNK3 (0.48) | ALDH1A1GAATDP1HPGDNPSR1 | |
| SCHEMBL18932675 | 0.64 | KCNK3 (0.48) | ALDH1A1GAATDP1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701686-B2 | Tricyclopyrazole derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-07-11 | — | — | US | disclosed |
| US-20150329552-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-11-19 | — | — | US | disclosed |
| US-9127015-B2 | Tricyclopyrazole derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-09-08 | — | — | US | disclosed |
| EP-2507244-B1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2014-11-05 | — | — | EP | disclosed |
| US-20120277214-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-11-01 | — | — | US | disclosed |
| EP-2507244-A1 | TRICYCLOPYRAZOLE DERIVATIVES | Nerviano Medical Sciences S.r.l. (IT) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067145-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329552-A1 | TRICYCLOPYRAZOLE DERIVATIVES | CDK3, MAP3K15, CDK6 | ALDH1A1 3563/4885MAPK1 136/4885GAA 1846/4885 |
| US-20120277214-A1 | TRICYCLOPYRAZOLE DERIVATIVES | CDK3, MAP3K15, CDK6 | ALDH1A1 3563/4885MAPK1 136/4885GAA 1846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.