Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 5/20 | 0.53 |
| ▸ | FEN1 | P39748 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960754 | 0.83 | EGLN1 (0.71) | EGLN1KDM4E | |
| SCHEMBL217059 | 0.78 | KMT2A (0.47) | SMN1; SMN2LMNATSHRFABP4HTT | |
| SCHEMBL3350444 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNATSHRPOLBFABP4 | |
| SCHEMBL11488105 | 0.76 | CNR1 (0.47) | ERCC5FEN1SMN1; SMN2LMNATSHR | |
| SCHEMBL27724198 | 0.75 | ERCC5 (0.61) | ERCC5FEN1SMN1; SMN2LMNATSHR | |
| SCHEMBL11609712 | 0.75 | NOTUM (0.57) | ERCC5FEN1SMN1; SMN2LMNATSHR | |
| SCHEMBL13401691 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNATSHRPOLBNOTUM | |
| SCHEMBL612585 | 0.73 | POLB (0.62) | SMN1; SMN2LMNATSHRPOLBFABP4 | |
| SCHEMBL5574170 | 0.72 | CNR2 (0.48) | ERCC5FEN1LMNATSHREGLN1 | |
| SCHEMBL27703560 | 0.72 | FEN1 (0.59) | ERCC5FEN1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | ERCC5 3011/4885FEN1 1383/4885SMN1; SMN2 3631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.