Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.42 |
| ▸ | RAF1 | P04049 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15432664 | 0.92 | SLC34A2 (0.45) | SLC34A2BRAFRAF1LCKMAPK14 | |
| SCHEMBL19579945 | 0.92 | SLC34A2 (0.45) | SLC34A2BRAFRAF1LCKMAPK14 | |
| SCHEMBL6002189 | 0.92 | SLC34A2 (0.44) | SLC34A2BRAFRAF1LCKMAPK14 | |
| SCHEMBL6002088 | 0.92 | SLC34A2 (0.44) | SLC34A2BRAFRAF1LCKMAPK14 | |
| SCHEMBL15432672 | 0.92 | SLC34A2 (0.45) | SLC34A2BRAFRAF1LCKMAPK14 | |
| SCHEMBL19595974 | 0.86 | BRAF (0.49) | SLC34A2EPHX2BRAFRAF1LCK | |
| SCHEMBL5998993 | 0.86 | BRAF (0.48) | SLC34A2EPHX2BRAFRAF1LCK | |
| SCHEMBL16808358 | 0.85 | ROCK2 (0.37) | SLC34A2CYP2C9CYP2C19SYKGSK3A | |
| SCHEMBL16365755 | 0.85 | ROCK2 (0.37) | SLC34A2CYP2C9CYP2C19SYKGSK3A | |
| SCHEMBL19596320 | 0.84 | BRAF (0.48) | SLC34A2EPHX2BRAFRAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |