Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892257 | 0.94 | TSHR (0.57) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL892519 | 0.89 | HSD17B10 (0.53) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL891991 | 0.87 | S1PR3 (0.55) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL27006476 | 0.86 | TSHR (0.50) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL31706300 | 0.85 | SMYD3 (0.53) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL31227843 | 0.85 | SMYD3 (0.53) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL31227420 | 0.84 | SMYD3 (0.54) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL21523828 | 0.83 | HCRTR2 (0.50) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL31644514 | 0.81 | HCRTR2 (0.47) | HCRTR2TSHRHSD17B10RAB9ANPC1 | |
| SCHEMBL17725866 | 0.80 | HCRTR2 (0.46) | HCRTR2TSHRHSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017504-B2 | Piperidine isoxazole and isothiazole orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170327490-A1 | PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10017504-B2 | Piperidine isoxazole and isothiazole orexin receptor antagonists | HCRTR1, HCRTR2, OXTR | HCRTR2 2/4885TSHR 178/4885HSD17B10 3211/4885 |
| US-20170327490-A1 | PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | HCRTR2 1/4885TSHR 211/4885HSD17B10 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.