Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.52 |
| ▸ | MTOR | P42345 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1118851 | 0.91 | PIK3CG (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL1118888 | 0.81 | PIK3CB (0.56) | PIK3CGPIK3CAPIK3CB | |
| SCHEMBL1961103 | 0.81 | HTR6 (0.36) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL1958201 | 0.81 | PIK3CG (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL1118916 | 0.79 | PIK3CG (0.51) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL1252454 | 0.78 | HTR6 (0.40) | PIK3CA | |
| SCHEMBL3662525 | 0.77 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3761617 | 0.76 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3770642 | 0.76 | PIK3CD (0.79) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL28800823 | 0.76 | PIK3CD (0.74) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507223-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF P13 KINASES | Glaxo Group Limited (GB) | 2012-10-10 | — | — | EP | disclosed |
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| WO-2011067365-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2011-06-09 | — | — | WO | disclosed |
| WO-2011067365-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | PIK3C3, PIK3CA, PIK3CD | PIK3CD 3/4885PIK3CG 14/4885PIK3CA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.