Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957094 | 0.87 | KDM4E (0.55) | KDM4EMAPTPKMPOLBADRB2 | |
| SCHEMBL1960127 | 0.84 | KDM4E (0.67) | KDM4EMAPTPKMPOLBGAA | |
| SCHEMBL1959246 | 0.83 | MAPT (0.57) | KDM4EBCL2MAPTPKMPOLB | |
| SCHEMBL1959258 | 0.80 | MAPT (0.53) | KDM4EBCL2MAPTPKMPOLB | |
| SCHEMBL28238037 | 0.78 | KDM4E (0.49) | KDM4EBCL2MAPTPKMPOLB | |
| SCHEMBL2481693 | 0.77 | MAPT (0.54) | MAPTPKMPOLBGAAKMT2A | |
| SCHEMBL20767652 | 0.77 | KDM4E (0.39) | KDM4EMAPTPKMGAAKMT2A | |
| SCHEMBL1956568 | 0.77 | KDM4E (0.47) | KDM4EBCL2MAPTPKMPOLB | |
| SCHEMBL2478539 | 0.75 | KDM4E (0.57) | KDM4EBCL2MAPTPKMPOLB | |
| SCHEMBL1957549 | 0.74 | MAPT (0.50) | MAPTPKMPOLBGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507211-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | claimed |
| WO-2011068560-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |