Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957094 | 0.79 | KDM4E (0.55) | KDM4EKMT2APKMSMN1; SMN2GAA | |
| SCHEMBL1960127 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1KMT2APKMALDH1A1 | |
| SCHEMBL1960223 | 0.77 | KDM4E (0.47) | KDM4EKMT2APKMSMN1; SMN2GAA | |
| SCHEMBL2408475 | 0.73 | MAPT (0.52) | L3MBTL1KMT2APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL1957524 | 0.72 | MAPT (0.47) | KDM4EL3MBTL1KMT2APKMALDH1A1 | |
| SCHEMBL1958960 | 0.72 | ALDH3A1 (0.48) | KMT2APKMMAPTMEN1 | |
| SCHEMBL28238037 | 0.71 | KDM4E (0.49) | KDM4EL3MBTL1KMT2APKMALDH1A1 | |
| SCHEMBL27202085 | 0.71 | BCL2L1 (0.59) | KMT2AMEN1 | |
| SCHEMBL30634506 | 0.71 | ABCC9 (0.39) | KDM4EL3MBTL1KMT2APKMALDH1A1 | |
| SCHEMBL29750920 | 0.70 | MAPT (0.45) | L3MBTL1KMT2APKMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672976-A1 | BCL-2 INHIBITORS | Newave Pharmaceutical Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019040573-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2019-02-28 | — | — | WO | disclosed |