Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948361 | 0.80 | CSNK2A2 (0.46) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL11994492 | 0.79 | ALOX5 (0.48) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL2940825 | 0.79 | SMN1; SMN2 (0.48) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL2940892 | 0.78 | HDAC8 (0.47) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL2940893 | 0.78 | HDAC8 (0.47) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL2939968 | 0.78 | SMN1; SMN2 (0.46) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL12939004 | 0.76 | ALOX5 (0.46) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL12939026 | 0.76 | HDAC8 (0.45) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL12939000 | 0.75 | SMN1; SMN2 (0.46) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL2946710 | 0.74 | SMN1; SMN2 (0.43) | ALOX5ALOX5APSMN1; SMN2CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10413550-B2 | Isoxazole compounds as inhibitors of heat shock proteins | THE INSTITUTE OF CANCER RESEARCH (GB) | 2019-09-17 | — | — | US | disclosed |
| US-20170326152-A1 | Isoxazole Compounds As Inhibitors Of Heat Shock Proteins | VERNALIS DEVELOPMENT LIMITED (GB) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326152-A1 | Isoxazole Compounds As Inhibitors Of Heat Shock Proteins | HSP90AB1, HSP90AA1, HSP90AB2P | ALOX5 2909/4885ALOX5AP 3670/4885SMN1; SMN2 2928/4885 |
| US-10413550-B2 | Isoxazole compounds as inhibitors of heat shock proteins | HSP90AB1, HSP90AA1, HSP90AB2P | ALOX5 2892/4885ALOX5AP 3660/4885SMN1; SMN2 2968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.