Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21366311 | 0.96 | KMT2A (0.39) | KMT2AMEN1RIPK1MAP3K5NOTUM | |
| SCHEMBL24349696 | 0.89 | NOTUM (0.46) | MAP3K5NOTUMTOP2AHSD17B3CYP2C9 | |
| SCHEMBL24408083 | 0.86 | TOP2A (0.38) | KMT2AMEN1MAP3K5NOTUMTOP2A | |
| SCHEMBL16202457 | 0.85 | KMT2A (0.39) | KMT2AMEN1RIPK1NOTUMMAPT | |
| SCHEMBL23280914 | 0.84 | KDM4E (0.48) | KMT2AMEN1MAP3K5NOTUMTOP2A | |
| SCHEMBL22512575 | 0.84 | HSD17B3 (0.48) | NOTUMMAPTHSD17B3ALDH1A1CYP2C9 | |
| SCHEMBL21396376 | 0.83 | SMN1; SMN2 (0.37) | KMT2AMEN1MAP3K5NOTUMTOP2A | |
| SCHEMBL25011607 | 0.83 | RIPK1 (0.34) | KMT2AMEN1RIPK1MAP3K5NOTUM | |
| SCHEMBL19687876 | 0.83 | KMT2A (0.34) | KMT2AMEN1RIPK1NOTUMHSD17B3 | |
| SCHEMBL25890666 | 0.83 | KMT2A (0.37) | KMT2AMEN1RIPK1NOTUMHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170326250-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326250-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | MKI67, CCNI, PA2G4 | KMT2A 2811/4885MEN1 846/4885RIPK1 3746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.