Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19610521 | 0.80 | PDE10A (0.38) | MAPTL3MBTL1KDM4EKMT2AHTT | |
| SCHEMBL19610580 | 0.80 | KDM4E (0.39) | MAPTKDM4EKMT2AHTTPKM | |
| SCHEMBL461099 | 0.77 | MAPT (0.69) | MAPTL3MBTL1KDM4EKMT2ACRHR1 | |
| SCHEMBL10005935 | 0.75 | MAPT (0.72) | MAPTL3MBTL1KDM4EKMT2ACRHR1 | |
| SCHEMBL27295502 | 0.74 | APP (0.34) | KDM4EKMT2ATSHRLMNAALDH1A1 | |
| SCHEMBL3051550 | 0.73 | MAPT (0.60) | MAPTL3MBTL1KDM4EKMT2ACRHR1 | |
| SCHEMBL2871982 | 0.72 | MAPT (0.57) | MAPTL3MBTL1KMT2ACRHR1PKM | |
| SCHEMBL29393886 | 0.71 | MAPT (0.57) | MAPTL3MBTL1KDM4EKMT2ACRHR1 | |
| SCHEMBL316994 | 0.71 | MAPT (0.57) | MAPTL3MBTL1KDM4EKMT2ACRHR1 | |
| SCHEMBL29410744 | 0.71 | MAPT (0.61) | MAPTL3MBTL1KDM4EKMT2ACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198756-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-23 | — | — | WO | disclosed |
| EP-3246028-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-22 | — | — | EP | disclosed |