Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17372585 | 0.86 | MAPT (0.56) | MAPTLMNAEGFRPOLBKDR | |
| SCHEMBL5518218 | 0.81 | MAPT (0.50) | MAPTLMNAPOLBPDE3BPDE3A | |
| SCHEMBL19610548 | 0.79 | ALDH1A1 (0.36) | PDPK1EGFRKDRPDE3BPDE3A | |
| SCHEMBL19610602 | 0.79 | SRC (0.40) | EGFRKDRERBB2KCNH2 | |
| SCHEMBL15647874 | 0.79 | EGFR (0.38) | MAPTEGFRPOLBKDRPDE3B | |
| SCHEMBL23520712 | 0.77 | PDE4A (0.42) | PDPK1EGFRPDE3BPDE3AFBP1 | |
| SCHEMBL2534877 | 0.77 | KDM4E (0.44) | MAPTPDPK1EGFRPOLBKDR | |
| SCHEMBL5036306 | 0.77 | MAPT (0.50) | MAPTLMNAPOLBPDE3BPDE3A | |
| SCHEMBL5522383 | 0.77 | MAPT (0.46) | MAPTLMNAPDE3BPDE3ANPC1 | |
| SCHEMBL29091604 | 0.75 | SMN1; SMN2 (0.44) | PDPK1EGFRKDRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198756-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-23 | — | — | WO | disclosed |
| EP-3246028-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-22 | — | — | EP | disclosed |