Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.76 |
| ▸ | DPP8 | Q6V1X1 | 10/20 | 0.66 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.66 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.66 |
| ▸ | ACE | P12821 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | FAP | Q12884 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL440941 | 1.00 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Monoethanolamine SCHEMBL1724443 | 1.00 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL439385 | 0.96 | DPP4 (0.81) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL409961 | 0.96 | DPP4 (0.81) | DPP4DPP8DPP9DPP7ACE | |
| Hydrochloric Acid SCHEMBL440700 | 0.96 | DPP4 (0.79) | DPP4DPP8DPP9DPP7ACE | |
| Hydrochloric Acid SCHEMBL440290 | 0.96 | DPP4 (0.79) | DPP4DPP8DPP9DPP7ACE | |
| Phosphoric Acid SCHEMBL441309 | 0.93 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Phosphoric Acid SCHEMBL441308 | 0.93 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Cadaverine Tartrate SCHEMBL443141 | 0.92 | DPP4 (0.75) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL441588 | 0.91 | DPP4 (0.75) | DPP4DPP8DPP9DPP7ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404921-B1 | SALTS OF TETRAHYDROIMIDAZO[1,5-a]PYRAZINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-11-22 | — | — | EP | disclosed |