Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.65 |
| ▸ | DPP4 | P27487 | 20/20 | 0.75 |
| ▸ | DPP8 | Q6V1X1 | 11/20 | 0.65 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.65 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.65 |
| ▸ | ACE | P12821 | 1/20 | 0.65 |
| ▸ | FAP | Q12884 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439385 | 0.96 | DPP4 (0.81) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL409961 | 0.96 | DPP4 (0.81) | DPP4DPP8DPP9DPP7ACE | |
| Hydrochloric Acid SCHEMBL440290 | 0.95 | DPP4 (0.79) | DPP4DPP8DPP9DPP7ACE | |
| Hydrochloric Acid SCHEMBL440700 | 0.95 | DPP4 (0.79) | DPP4DPP8DPP9DPP7ACE | |
| Malic Acid SCHEMBL440815 | 0.93 | DPP4 (0.71) | DPP4DPP8DPP9DPP7ACE | |
| Monoethanolamine SCHEMBL1724443 | 0.92 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Monoethanolamine SCHEMBL19611144 | 0.92 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Monoethanolamine SCHEMBL440941 | 0.92 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Phosphoric Acid SCHEMBL441309 | 0.92 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| Phosphoric Acid SCHEMBL441308 | 0.92 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065209-A1 | TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-03-15 | — | — | US | disclosed |
| EP-2404921-A1 | SALTS OF TETRAHYDROIMIDAZO Ý1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2012-01-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065209-A1 | TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF | DPP4, DPP7, DPP3 | HTR2A 1747/4885DPP4 1/4885DPP8 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.