Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | FABP6 | P51161 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234988 | 0.82 | HRH3 (0.61) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL2377995 | 0.82 | HRH3 (0.61) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL10724841 | 0.80 | POLB (0.81) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL11955563 | 0.80 | HRH3 (0.66) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL3754883 | 0.80 | HRH3 (0.66) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL19611154 | 0.80 | HPGD (0.66) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL2378879 | 0.79 | HRH3 (0.58) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL2377726 | 0.78 | HRH3 (0.64) | HRH3POLBHPGDALOX15LMNA | |
| SCHEMBL16281084 | 0.78 | HRH3 (0.64) | HRH3POLBHPGDALOX15LMNA | |
| Hydrochloric Acid SCHEMBL7016300 | 0.77 | HRH3 (0.67) | HRH3POLBHPGDALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | claimed |