Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724841 | 0.87 | POLB (0.81) | HPGDALOX15POLBKMT2AMEN1 | |
| SCHEMBL6471455 | 0.86 | HPGD (0.68) | HPGDKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL9683013 | 0.84 | HPGD (0.71) | HPGDKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL19611151 | 0.84 | L3MBTL3 (0.64) | HPGDPOLBKMT2AMEN1CYP2D6 | |
| SCHEMBL20465807 | 0.83 | EPHX2 (0.69) | HPGDALOX15POLBKMT2AMEN1 | |
| SCHEMBL21551794 | 0.83 | POLB (0.65) | HPGDALOX15POLBKMT2AMEN1 | |
| SCHEMBL20449050 | 0.82 | POLB (0.86) | HPGDALOX15POLBKMT2AMEN1 | |
| SCHEMBL17560151 | 0.81 | PHGDH (0.63) | HPGDPOLBKMT2AEPHX2TSHR | |
| SCHEMBL16731045 | 0.81 | EPHX2 (0.74) | HPGDALOX15POLBKMT2AMEN1 | |
| SCHEMBL14980308 | 0.80 | POLB (0.72) | HPGDALOX15POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | claimed |