SCHEMBL1961187

SCHEMBL1961187

O=CC(Br)c1ccc(Cl)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.47
LMNA P02545 2/20 0.47
HTT P42858 1/20 0.47
TDP1 Q9NUW8 1/20 0.45
IDO1 P14902 1/20 0.38
TDO2 P48775 1/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TSHR P16473 3/20 0.35
HSD17B10 Q99714 1/20 0.35
CYP3A4 P08684 1/20 0.35
CASP1 P29466 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 1/20 0.35
GAA P10253 1/20 0.35
MGAM O43451 1/20 0.35
POLB P06746 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21495096 1.00 TP53 (0.47) TP53LMNAHTTTDP1IDO1
SCHEMBL2311541 0.84 TDP1 (0.41) TP53LMNAHTTTDP1MEN1
SCHEMBL20551400 0.81 MDM2 (0.38) TP53LMNAHTTTDP1KMT2A
SCHEMBL2932458 0.81 MDM2 (0.39) LMNAHTTSMN1; SMN2ALDH1A1
SCHEMBL20551407 0.81 MDM2 (0.39) LMNAHTTSMN1; SMN2ALDH1A1
SCHEMBL8805467 0.81 TSHR (0.43) TP53LMNAHTTTDP1MEN1
SCHEMBL846656 0.81 GABRA1 (0.33) TP53LMNAHTTMEN1KMT2A
SCHEMBL7575571 0.79 TP53 (0.50) TP53LMNAHTTTDP1IDO1
SCHEMBL6443959 0.78 TDP1 (0.35) TDP1HSD17B10
SCHEMBL26664767 0.78 TDP1 (0.35) TDP1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012164572-A1 SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2012-12-06 WO claimed
EP-3619209-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS Glenmark Pharmaceuticals S.A. (CH) 2020-03-11 EP disclosed
WO-2018203298-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2018-11-08 WO disclosed
EP-3325471-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS Genzyme Corporation (US) 2018-05-30 EP disclosed
EP-3226858-A1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS Procomcure Biotech GmbH (AT) 2017-10-11 EP disclosed
WO-2017015267-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2017-01-26 WO disclosed
EP-3049084-A1 NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION Cortendo AB (publ) (US) 2016-08-03 EP disclosed
WO-2016087616-A1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS PROCOMCURE BIOTECH GMBH (AT) 2016-06-09 WO disclosed
WO-2016087615-A1 NOVEL IMIDAZOLE-BASED HETEROCYCLIC COMPOUNDS PROCOMCURE BIOTECH GMBH (AT) 2016-06-09 WO disclosed
WO-2016087618-A1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS PROCOMCURE BIOTECH GMBH (AT) 2016-06-09 WO disclosed
EP-1748982-A1 (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE MERCK SHARP & DOHME LTD. (GB) 2007-02-07 EP disclosed
WO-2005108362-A1 (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE MERCK SHARP & DOHME LIMITED (GB) 2005-11-17 WO disclosed
EP-1583742-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-12 EP disclosed
WO-2004060870-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-22 WO disclosed
EP-1194144-A4 ANTIBACTERIAL COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2002-08-07 EP disclosed
EP-1194144-A1 ANTIBACTERIAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-10 EP disclosed
EP-0891978-B1 5H-Thiazolo (3,2-a) pyrimidine derivatives HOFFMANN LA ROCHE (CH) 2002-03-20 EP disclosed
WO-2000071120-A1 ANTIBACTERIAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2000-11-30 WO disclosed
US-5958931-A NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-09-28 US disclosed
EP-0891978-A2 5H-Thiazolo (3,2-a) pyrimidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-01-20 EP disclosed