Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19636843 | 0.92 | GRM4 (0.35) | GRM4AGPAT2NAMPTNOTUMMEN1 | |
| SCHEMBL19614901 | 0.90 | ERBB2 (0.42) | GRM4ERBB2 | |
| SCHEMBL19633219 | 0.87 | AGPAT2 (0.40) | GRM4AGPAT2NAMPTNOTUMMEN1 | |
| SCHEMBL19633019 | 0.86 | GRM4 (0.37) | GRM4AGPAT2NAMPTNOTUMMEN1 | |
| Hydrochloric Acid SCHEMBL30464368 | 0.86 | ERBB2 (0.38) | GRM4AGPAT2KDM4EMAPTHTR2C | |
| Hydrochloric Acid SCHEMBL19614868 | 0.86 | ERBB2 (0.38) | GRM4AGPAT2KDM4EMAPTHTR2C | |
| Hydrochloric Acid SCHEMBL30464353 | 0.85 | GRM4 (0.37) | GRM4AGPAT2NAMPTNOTUMMEN1 | |
| SCHEMBL19633039 | 0.85 | ERBB2 (0.40) | GRM4AGPAT2NAMPTMEN1KMT2A | |
| SCHEMBL19632860 | 0.84 | ERBB2 (0.42) | GRM4AGPAT2NAMPTERBB2 | |
| Hydrochloric Acid SCHEMBL30464360 | 0.84 | ERBB2 (0.40) | GRM4AGPAT2NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458069-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS INC (US) | 2023-07-05 | — | — | EP | disclosed |
| US-10660901-B2 | Pyrrolobenzodiazepines and conjugates thereof | MERSANA THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3458069-A2 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | Mersana Therapeutics, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| US-20190070194-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. | 2019-03-07 | — | — | US | disclosed |
| US-10143695-B2 | Pyrrolobenzodiazepines and conjugates thereof | MERSANA THERAPEUTICS, INC. (US) | 2018-12-04 | — | — | US | disclosed |
| WO-2017201132-A2 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| US-20170333442-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333442-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD79B, CLTB, FCGR3B | GRM4 830/4885AGPAT2 4249/4885NAMPT 3033/4885 |
| US-20190070194-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD79B, CLTB, FCGR3B | GRM4 830/4885AGPAT2 4249/4885NAMPT 3033/4885 |
| US-10143695-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD79B, CLTB, FCGR3B | GRM4 830/4885AGPAT2 4249/4885NAMPT 3033/4885 |
| US-10660901-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD79B, CLTB, FCGR3B | GRM4 830/4885AGPAT2 4249/4885NAMPT 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.