Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 7/20 | 0.39 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.36 |
| ▸ | KDM5A | P29375 | 5/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.36 |
| ▸ | KDM5C | P41229 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 3/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.35 |
| ▸ | KDM6B | O15054 | 2/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615743 | 0.91 | CA2 (0.40) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19616073 | 0.89 | KMT2A (0.41) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19616087 | 0.87 | MEN1 (0.41) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19631830 | 0.87 | MEN1 (0.42) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19615934 | 0.86 | KDM2B (0.40) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19615910 | 0.86 | MEN1 (0.46) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19632168 | 0.85 | KDM4C (0.43) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19615741 | 0.85 | MEN1 (0.39) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19615817 | 0.85 | MEN1 (0.44) | MEN1KMT2ACA2CA1CA12 | |
| SCHEMBL19632113 | 0.84 | KDM1A (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |