Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | KMO | O15229 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.46 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.46 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615998 | 0.88 | MEN1 (0.50) | MRGPRX4KDM4EALDH1A1KDM5AKDM4C | |
| SCHEMBL19615987 | 0.85 | KDM4C (0.48) | MRGPRX4KMOKDM4EALDH1A1KDM5A | |
| SCHEMBL19616024 | 0.85 | NR4A2 (0.51) | MRGPRX4KDM4EALDH1A1KDM5AKDM4C | |
| SCHEMBL19631994 | 0.84 | KDM6B (0.51) | KDM4EALDH1A1KDM5AKDM4CKDM5B | |
| SCHEMBL19632083 | 0.83 | PTPN7 (0.51) | MRGPRX4KDM4EALDH1A1KDM5AKDM4C | |
| SCHEMBL19615536 | 0.83 | KDM5A (0.48) | MRGPRX4KDM4EALDH1A1KDM5AKDM4C | |
| SCHEMBL19615734 | 0.83 | KDM4C (0.48) | MRGPRX4KDM4EALDH1A1KDM5AKDM4C | |
| SCHEMBL19631870 | 0.83 | KDM4C (0.48) | KDM4EALDH1A1KDM5AKDM4CKDM5B | |
| Hydrochloric Acid SCHEMBL19615770 | 0.82 | PTPN7 (0.50) | MRGPRX4KDM4EALDH1A1KDM5AKDM4C | |
| SCHEMBL19615967 | 0.82 | MAPT (0.47) | KDM4EALDH1A1KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | claimed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |