SCHEMBL19632083

SCHEMBL19632083

O=C(O)c1ccnc(/C(COc2ccc3ccccc3c2)=N/O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN7 P35236 1/20 0.51
MRGPRX4 Q96LA9 2/20 0.49
MEN1 O00255 6/20 0.48
KMT2A Q03164 6/20 0.48
MAPT P10636 5/20 0.48
HTT P42858 3/20 0.48
PPARG P37231 2/20 0.46
NCOA2 Q15596 2/20 0.46
NCOA1 Q15788 2/20 0.46
NCOA3 Q9Y6Q9 2/20 0.46
POLB P06746 1/20 0.46
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 1/20 0.46
KDM6B O15054 1/20 0.46
TET3 O43151 1/20 0.46
KDM4A O75164 1/20 0.46
BBOX1 O75936 1/20 0.46
KDM5A P29375 1/20 0.46
KDM5C P41229 1/20 0.46
ASPH Q12797 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL19615770 0.99 PTPN7 (0.50) PTPN7MRGPRX4MEN1KMT2AMAPT
SCHEMBL19631994 0.89 KDM6B (0.51) MAPTALDH1A1KDM4EKDM6BTET3
SCHEMBL19615967 0.87 MAPT (0.47) MEN1KMT2AMAPTPPARGALDH1A1
SCHEMBL19615974 0.87 KDM6B (0.47) MAPTHTTPOLBALDH1A1KDM4E
SCHEMBL19615641 0.85 PLA2G4B (0.54) MRGPRX4MEN1KMT2APOLBKDM5A
SCHEMBL19615487 0.85 MRGPRX4 (0.51) MRGPRX4MAPTALDH1A1KDM4EKDM6B
SCHEMBL19615654 0.85 AKR1C3 (0.49) MAPTHTTPPARGPOLBALDH1A1
SCHEMBL19615979 0.83 MRGPRX4 (0.48) MRGPRX4MEN1KMT2AMAPTALDH1A1
SCHEMBL19631870 0.83 KDM4C (0.48) MEN1KMT2AMAPTALDH1A1KDM4E
SCHEMBL19615998 0.83 MEN1 (0.50) MRGPRX4MEN1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017198785-A1 OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2017-11-23 WO disclosed