Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.40 |
| ▸ | ADH1B | P00325 | 1/20 | 0.40 |
| ▸ | ADH1C | P00326 | 1/20 | 0.40 |
| ▸ | ADH1A | P07327 | 1/20 | 0.40 |
| ▸ | ADH4 | P08319 | 1/20 | 0.40 |
| ▸ | ADH7 | P40394 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368880 | 0.85 | ALDH1A1 (0.46) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL38660495 | 0.85 | EPHX1 (0.44) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| Hydrochloric Acid SCHEMBL29449809 | 0.85 | EPHX1 (0.44) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL14470686 | 0.83 | TSHR (0.40) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL21857757 | 0.82 | ALDH1A1 (0.38) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL10593520 | 0.82 | EPHX1 (0.46) | TSHRALDH1A1EPHX1ADH1BADH1C | |
| SCHEMBL28390348 | 0.80 | TSHR (0.62) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL25435977 | 0.79 | TSHR (0.87) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL868091 | 0.79 | TSHR (0.87) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL21113627 | 0.79 | TSHR (0.87) | TSHRALDH1A1S1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458108-A1 | POLYNUCLEOTIDES ENCODING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS | ModernaTX, Inc. (US) | 2019-03-27 | — | — | EP | claimed |
| WO-2017201347-A1 | POLYNUCLEOTIDES ENCODING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS | MODERNATX, INC. (US) | 2017-11-23 | — | — | WO | claimed |