Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616956 | 0.92 | KRAS (0.47) | KRASMTOR | |
| SCHEMBL30188858 | 0.88 | KRAS (0.58) | KRAS | |
| SCHEMBL19637181 | 0.88 | KRAS (0.58) | KRAS | |
| SCHEMBL19616951 | 0.87 | KRAS (0.59) | KRAS | |
| SCHEMBL22440233 | 0.85 | KRAS (0.48) | KRAS | |
| SCHEMBL22440324 | 0.84 | KRAS (0.59) | KRAS | |
| SCHEMBL22440384 | 0.84 | KRAS (0.45) | KRASMTOR | |
| SCHEMBL19616730 | 0.82 | KRAS (0.44) | KRAS | |
| SCHEMBL19637328 | 0.81 | KRAS (0.42) | KRAS | |
| SCHEMBL19959212 | 0.81 | KRAS (0.59) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458445-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |