Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18294576 | 0.85 | CYP11B1 (0.50) | JAK2MTORGAANPSR1KDM4E | |
| SCHEMBL18293595 | 0.85 | GAA (0.44) | GAANPSR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL18294600 | 0.83 | GAA (0.61) | JAK2MTORGAANPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL15716897 | 0.82 | GAA (0.60) | JAK2MTORGAANPSR1KDM4E | |
| SCHEMBL15729914 | 0.81 | JAK2 (0.42) | JAK2MTORGAANPSR1KDM4E | |
| SCHEMBL18293602 | 0.78 | GAA (0.64) | GAANPSR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL22146345 | 0.70 | ALDH1A1 (0.47) | GAANPSR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL14810539 | 0.69 | CYP11B1 (0.55) | GAANPSR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL13561321 | 0.69 | CYP2A6 (0.46) | JAK2MTORCYP2A6PIK3CAHSD17B1 | |
| SCHEMBL10094701 | 0.68 | CYP2A6 (0.57) | MTORKDM4EALDH1A1HPGDCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822118-B2 | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-11-21 | — | — | US | disclosed |