Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GALR3 | O60755 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8943709 | 1.00 | HDAC3 (0.60) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1959030 | 0.98 | HDAC3 (0.61) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1963055 | 0.98 | HDAC3 (0.61) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1961830 | 0.98 | HDAC3 (0.61) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1963183 | 0.98 | HDAC3 (0.61) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9512254 | 0.98 | HDAC3 (0.61) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL11441828 | 0.97 | HDAC3 (0.60) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL11429908 | 0.97 | HDAC3 (0.60) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Iodide SCHEMBL11872589 | 0.97 | HDAC3 (0.60) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9161505 | 0.97 | HDAC3 (0.59) | HDAC3ALDH1A1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144079-A1 | ANTIMICROBIAL SYSTEM | THE QUEEN'S UNIVERSITY OF BELFAST (GB) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144079-A1 | ANTIMICROBIAL SYSTEM | PIK3C3, POLR1C, LTN1 | SIGMAR1 1646/4885HDAC3 4564/4885ALDH1A1 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.