Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620621 | 0.84 | MAPT (0.49) | KMT2AKDM4EPOLBMAPTALDH1A1 | |
| SCHEMBL19620630 | 0.79 | HCRTR1 (0.37) | POLBALDH1A1 | |
| SCHEMBL15627599 | 0.79 | KDM4E (0.41) | MEN1KMT2AKDM4EPOLBMAPT | |
| SCHEMBL19620692 | 0.79 | DPP4 (0.38) | KDM4EPOLBMAPTEPHX2 | |
| SCHEMBL19620539 | 0.79 | CYP1A2 (0.33) | KDM4EPOLBMAPTALDH1A1EPHX2 | |
| SCHEMBL20367974 | 0.79 | MAPT (0.41) | MEN1KMT2AKDM4EPOLBMAPT | |
| SCHEMBL19620541 | 0.78 | KDM4E (0.37) | KDM4EPOLBMAPTEPHX2 | |
| SCHEMBL19620538 | 0.78 | KDM4E (0.37) | KDM4EPOLBMAPTEPHX2 | |
| SCHEMBL19620575 | 0.77 | POLB (0.36) | MEN1KMT2ARUNX1CBFBKDM4E | |
| SCHEMBL19620531 | 0.77 | MAPT (0.39) | KDM4EPOLBMAPTALDH1A1FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |