Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620621 | 0.89 | MAPT (0.49) | MAPTKDM4EPOLBTP53ALDH1A1 | |
| SCHEMBL22902015 | 0.84 | PTAFR (0.37) | MAPTKDM4ETP53MDM2ALDH1A1 | |
| SCHEMBL20367974 | 0.81 | MAPT (0.41) | MAPTKDM4EPOLBMDM2ALDH1A1 | |
| SCHEMBL15627599 | 0.81 | KDM4E (0.41) | MAPTKDM4EPOLB | |
| SCHEMBL20368252 | 0.81 | MAPT (0.39) | MAPTKDM4EPOLBTP53MDM2 | |
| SCHEMBL22902083 | 0.81 | KDM4E (0.39) | MAPTKDM4EPOLBALDH1A1CYP19A1 | |
| SCHEMBL19620541 | 0.81 | KDM4E (0.37) | MAPTKDM4EPOLBCYP19A1CYP3A4 | |
| SCHEMBL19620538 | 0.81 | KDM4E (0.37) | MAPTKDM4EPOLBCYP3A4 | |
| SCHEMBL19620623 | 0.80 | MAPT (0.40) | MAPTKDM4EPOLBTP53ALDH1A1 | |
| SCHEMBL19620620 | 0.79 | LMNA (0.38) | MAPTKDM4EPOLBALDH1A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |