Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.52 |
| ▸ | EZH1 | Q92800 | 5/20 | 0.51 |
| ▸ | EED | O75530 | 4/20 | 0.46 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.46 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180398 | 0.87 | EZH2 (0.54) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16360817 | 0.86 | EZH2 (0.56) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL12180072 | 0.85 | EZH2 (0.58) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16360919 | 0.83 | EZH2 (0.54) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19620792 | 0.83 | EZH2 (0.63) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2594608 | 0.83 | EZH2 (0.53) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL12180461 | 0.81 | EZH2 (0.64) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180425 | 0.81 | EZH2 (0.52) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2591361 | 0.80 | EZH2 (0.65) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL16360815 | 0.80 | EZH2 (0.54) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |