Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.48 |
| ▸ | EZH1 | Q92800 | 10/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.46 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.46 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.46 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.46 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18864299 | 0.88 | EZH1 (0.64) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL2594600 | 0.84 | EZH2 (0.65) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL19621017 | 0.80 | EZH2 (0.40) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL12180079 | 0.77 | EZH2 (0.62) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL20991983 | 0.77 | EZH1 (0.70) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL12180070 | 0.76 | EZH2 (0.66) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL18863725 | 0.75 | EZH2 (0.44) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL2592665 | 0.75 | EZH2 (0.67) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL2595015 | 0.75 | EZH2 (0.65) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL19621023 | 0.75 | EZH2 (0.43) | EZH2EZH1PRMT3EEDRBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |