Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 14/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872584 | 0.77 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL2378615 | 0.74 | PIK3CA (0.60) | PIK3CAPIK3R1ALDH1A1LMNA | |
| SCHEMBL19623320 | 0.72 | KMT2A (0.40) | PIK3CAPIK3R1PIK3CDPIK3CBALDH1A1 | |
| SCHEMBL13012640 | 0.72 | PIK3CA (0.49) | PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL2378251 | 0.70 | HTR2C (0.44) | PIK3CAPIK3R1ALDH1A1LMNA | |
| SCHEMBL12247675 | 0.70 | ALDH1A1 (0.56) | PIK3CAPIK3R1PIK3CDPIK3CBALDH1A1 | |
| SCHEMBL20708218 | 0.69 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL13872927 | 0.68 | PIK3CA (0.60) | PIK3CAPIK3R1 | |
| SCHEMBL16684483 | 0.68 | PIK3CA (0.37) | PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL2376887 | 0.65 | KDM4E (0.48) | PIK3CAPIK3R1PIK3CDPIK3CBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |