Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623825 | 0.83 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2376638 | 0.82 | PIK3CA (0.72) | PIK3CAMTOR | |
| SCHEMBL19623809 | 0.80 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2377668 | 0.78 | PIK3CA (0.65) | PIK3CAMTOR | |
| SCHEMBL19623722 | 0.77 | PIK3CA (0.46) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL12247608 | 0.75 | PIK3CA (0.72) | PIK3CA | |
| SCHEMBL2376748 | 0.73 | PIK3CA (0.69) | PIK3CA | |
| SCHEMBL19623577 | 0.72 | MTOR (0.43) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL12247568 | 0.72 | PIK3CA (0.79) | PIK3CA | |
| Trifluoroacetic Acid SCHEMBL2377793 | 0.71 | PIK3CA (0.66) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |