Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623825 | 0.91 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CGKDM1AHDAC1 | |
| SCHEMBL2376111 | 0.81 | PIK3CA (0.77) | PIK3CA | |
| SCHEMBL19623596 | 0.80 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL19623703 | 0.79 | PIK3CA (0.49) | PIK3CAPIK3CGNAMPTALDH1A1MAPK8 | |
| SCHEMBL19623722 | 0.79 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL19623791 | 0.78 | SMN1; SMN2 (0.54) | PIK3CAALDH1A1MAPK8MAPK10MAPK14 | |
| SCHEMBL2379928 | 0.76 | PIK3CA (0.67) | PIK3CA | |
| SCHEMBL2376373 | 0.75 | PIK3CA (0.78) | PIK3CA | |
| SCHEMBL3832685 | 0.74 | PIK3CA (0.75) | PIK3CA | |
| SCHEMBL2377284 | 0.73 | PIK3CA (0.79) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |