Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376610 | 0.75 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL19611202 | 0.73 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL19623563 | 0.73 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL2818215 | 0.72 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL12248080 | 0.72 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL2376765 | 0.72 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL2377619 | 0.71 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3R1MTOR | |
| SCHEMBL19611250 | 0.70 | PIK3CA (0.52) | PIK3CAPIK3R1 | |
| SCHEMBL2375987 | 0.70 | HTR7 (0.42) | — | |
| SCHEMBL19611160 | 0.68 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |