SCHEMBL19625812

SCHEMBL19625812

CC(=O)OCCC1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.69
LMNA P02545 9/20 0.69
ALDH1A1 P00352 6/20 0.69
MAPT P10636 6/20 0.69
SMN1; SMN2 Q16637 5/20 0.69
MEN1 O00255 2/20 0.69
KMT2A Q03164 2/20 0.69
TSHR P16473 5/20 0.64
NR3C1 P04150 5/20 0.64
PGR P06401 5/20 0.64
MAPK1 P28482 4/20 0.64
SHBG P04278 4/20 0.64
SERPINA6 P08185 4/20 0.64
AR P10275 4/20 0.64
CYP2C9 P11712 3/20 0.64
GPBAR1 Q8TDU6 3/20 0.64
SIGMAR1 Q99720 3/20 0.64
NR1I2 O75469 3/20 0.64
HIF1A Q16665 2/20 0.64
ABCB11 O95342 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23223005 1.00 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL22475766 1.00 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL7596559 0.92 PSEN1 (0.63) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL6465617 0.90 CYP3A4 (0.72) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL6465612 0.90 CYP3A4 (0.72) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL21367235 0.85 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL19635112 0.85 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL22475606 0.85 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL10796253 0.85 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL20402646 0.85 CYP3A4 (0.69) CYP3A4LMNAALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017199036-A1 PROCESS AND INTERMEDIATES FOR THE 6,7-ALPHA-EPOXIDATION OF STEROID 4,6-DIENES NZP UK Limited (GB) 2017-11-23 WO disclosed
WO-2017199033-A1 INTERMEDIATES FOR THE SYNTHESIS OF BILE ACID DERIVATIVES, IN PARTICULAR OF OBETICHOLIC ACID NZP UK Limited (GB) 2017-11-23 WO disclosed