Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 15/20 | 0.57 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952950 | 0.90 | PTGER4 (0.71) | PTGER4PTGDRPTGER3PTGER2 | |
| SCHEMBL1844419 | 0.90 | PTGER4 (0.71) | PTGER4PTGDRPTGER3PTGER2 | |
| SCHEMBL196278 | 0.83 | PTGER4 (0.51) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL13492636 | 0.83 | MMP13 (0.51) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL1844421 | 0.81 | PTGER4 (0.48) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL1845535 | 0.79 | KDM4E (0.45) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28482882 | 0.78 | PTGER4 (0.58) | PTGER4PTGDRPTGER2 | |
| SCHEMBL1955609 | 0.78 | PTGER4 (0.58) | PTGER4PTGDRPTGER2 | |
| SCHEMBL26951177 | 0.78 | PTGER4 (0.55) | PTGER4PTGDRPTGER2 | |
| SCHEMBL12571984 | 0.78 | PTGER4 (0.56) | PTGER4PTGDRPTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500211-A | — | — | 2012-01-05 | — | — | JP | claimed |
| EP-2320906-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Beta Pharma Canada Inc. (CA) | 2011-05-18 | — | — | EP | claimed |
| WO-2010019796-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | CHEMIETEK, LLC (US) | 2010-02-18 | — | — | WO | claimed |