Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 13/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31259879 | 0.86 | SMPD3 (0.64) | SMPD3MAPTALDH1A1MAPK1POLB | |
| SCHEMBL31259866 | 0.84 | SMPD3 (0.67) | SMPD3LMNA | |
| SCHEMBL31259903 | 0.84 | SMPD3 (0.67) | SMPD3LMNA | |
| SCHEMBL22175268 | 0.82 | SMPD3 (0.48) | SMPD3 | |
| SCHEMBL31349250 | 0.81 | MAPT (0.41) | SMPD3MAPTALDH1A1CCNT1FLT3 | |
| SCHEMBL29015967 | 0.81 | KDM4E (0.44) | SMPD3MAPTALDH1A1CCNT1FLT3 | |
| SCHEMBL20015889 | 0.77 | SMPD3 (0.62) | SMPD3 | |
| SCHEMBL20015989 | 0.76 | SMPD3 (0.63) | SMPD3 | |
| SCHEMBL24689691 | 0.75 | SMPD3 (0.68) | SMPD3 | |
| SCHEMBL15989384 | 0.75 | SMPD3 (0.68) | SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3800189-B1 | PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE | LOXO ONCOLOGY INC (US) | 2023-06-28 | — | — | EP | disclosed |
| WO-2023082465-A1 | METHOD FOR PREPARING AMINO ALCOHOL BY ASYMMETRIC HYDROGENATION AND APPLICATION THEREOF | 凯特立斯（深圳）科技有限公司 | 2023-05-19 | — | — | WO | disclosed |
| EP-3800189-A1 | PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE | Loxo Oncology Inc. (US) | 2021-04-07 | — | — | EP | disclosed |
| EP-3458456-B1 | PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE | LOXO ONCOLOGY INC (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2020135203-A1 | PHARMACEUTICAL COMPOUND, COMPOSITION THEREOF, AND APPLICATION | 上海度德医药科技有限公司 | 2020-07-02 | — | — | WO | disclosed |
| WO-2017201241-A1 | PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-Y L)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE | REYNOLDS MARK (US) | 2017-11-23 | — | — | WO | disclosed |