Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 17/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20015889 | 0.99 | SMPD3 (0.62) | SMPD3PIM1PIM2IRAK4 | |
| SCHEMBL860108 | 0.87 | SMPD3 (0.50) | SMPD3PARP1IRAK4 | |
| SCHEMBL12979110 | 0.78 | SMPD3 (0.51) | SMPD3PIM1PIM2IRAK4 | |
| SCHEMBL861194 | 0.78 | SMPD3 (0.51) | SMPD3PIM1PIM2IRAK4 | |
| SCHEMBL861193 | 0.78 | SMPD3 (0.51) | SMPD3PIM1PIM2IRAK4 | |
| SCHEMBL19560147 | 0.78 | SMPD3 (0.58) | SMPD3IRAK4 | |
| SCHEMBL31259868 | 0.78 | SMPD3 (1.00) | SMPD3PARP1 | |
| SCHEMBL20015997 | 0.78 | SMPD3 (0.68) | SMPD3 | |
| SCHEMBL21996850 | 0.77 | SMPD3 (0.63) | SMPD3IRAK4 | |
| SCHEMBL19631256 | 0.76 | SMPD3 (0.59) | SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299372-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OFSUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2018-03-28 | — | — | EP | disclosed |