⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23396 | 0.93 | — | — | |
| Water SCHEMBL18345413 | 0.86 | LMNA (0.38) | — | |
| Water SCHEMBL15902637 | 0.86 | LMNA (0.38) | — | |
| Water SCHEMBL18237167 | 0.86 | LMNA (0.38) | — | |
| Water SCHEMBL4479154 | 0.86 | — | — | |
| Water SCHEMBL16010847 | 0.86 | — | — | |
| Water SCHEMBL3326761 | 0.86 | LMNA (0.38) | — | |
| Water SCHEMBL15902365 | 0.86 | LMNA (0.38) | — | |
| SCHEMBL1994070 | 0.80 | — | — | |
| SCHEMBL1992930 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263594-B2 | Aryloxy and arylalkyleneoxy substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-09-11 | — | — | US | disclosed |
| US-20110144099-A1 | ARYLOXY AND ARYLALKYLENEOXY SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES COMPANY | 2011-06-16 | — | — | US | disclosed |
| US-6440989-B2 | ANTITUMOR AGENT | SCHERING CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-20010016585-A1 | Novel phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase | AFONSO ADRIANO (IN) | 2001-08-23 | — | — | US | disclosed |
| US-6218401-B1 | FOR THERAPY OF PANCREATIC TUMOR CELLS, LUNG CANCER CELLS, MYELOID LEUKEMIA TUMOR CELLS, THYROID FOLLICULAR TUMOR CELLS, MYELODYSPLASTIC TUMOR CELLS, EPIDERMAL CARCINOMA TUMOR CELLS, BLADDER CARCINOMA TUMOR CELLS OR PROSTATE TUMOR CELLS | SCHERING CORPORATION | 2001-04-17 | — | — | US | disclosed |
| EP-0989981-A1 | NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998057950-A1 | NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |
| US-5451581-A | BACTERICIDES | AMERICAN CYANAMID COMPANY | 1995-09-19 | — | — | US | disclosed |