Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL937298 | 0.91 | MAPT (0.64) | MAPTLMNATP53NPSR1SMN1; SMN2 | |
| SCHEMBL197113 | 0.90 | MAPT (0.57) | MAPTLMNATP53NPSR1SMN1; SMN2 | |
| SCHEMBL197225 | 0.89 | NPC1 (0.49) | TP53MEN1RAB9AKMT2AADORA3 | |
| SCHEMBL14856838 | 0.88 | NPC1 (0.51) | MAPTTP53RAB9AGRM4 | |
| SCHEMBL196331 | 0.87 | NPC1 (0.46) | TP53SMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL934924 | 0.82 | IGF1R (0.52) | MAPTTP53MEN1RAB9AKMT2A | |
| SCHEMBL196744 | 0.81 | MAPT (0.58) | MAPTSMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL196377 | 0.80 | GRM4 (0.49) | MAPTTP53RAB9AADORA3GRM4 | |
| SCHEMBL196681 | 0.80 | RXFP1 (0.53) | MAPTMEN1RAB9AKMT2AIGF1R | |
| SCHEMBL935627 | 0.80 | RXFP1 (0.51) | MAPTTP53NPSR1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500255-A | — | — | 2012-01-05 | — | — | JP | claimed |
| EP-2323661-A1 | A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS | Universiteit Leiden (NL) | 2011-05-25 | — | — | EP | claimed |
| WO-2010020981-A1 | A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS | UNIVERSITEIT LEIDEN (NL) | 2010-02-25 | — | — | WO | claimed |