Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | FAAH | O00519 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7761440 | 0.94 | MAPT (0.86) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL11085067 | 0.94 | MAPT (0.86) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL2433131 | 0.91 | MAPT (0.75) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL16610098 | 0.88 | MAPT (0.84) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL28851928 | 0.87 | MAPT (0.83) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL5447936 | 0.86 | FAAH (0.66) | MAPTFAAHCYP3A4TRPV1HTT | |
| SCHEMBL16353626 | 0.85 | MAPT (0.81) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL19456982 | 0.85 | MAPT (0.74) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL31321081 | 0.84 | MAPT (0.69) | MAPTFAAHCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10023 | 0.84 | MAPT (0.69) | MAPTFAAHCYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197488-A1 | LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | CYCLENIUM PHARMA INC. (CA) | 2017-11-23 | — | — | WO | disclosed |