SCHEMBL19632918

SCHEMBL19632918

C=CCC1(F)CC1Cc1nnc2c(Cl)c(-c3ccc4c(c3)OCO4)ccn12

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 20/20 0.77
KCNH2 Q12809 7/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20836149 0.87 GRM2 (1.00) GRM2KCNH2
SCHEMBL19633012 0.79 GRM2 (1.00) GRM2KCNH2
SCHEMBL19632766 0.77 GRM2 (0.80) GRM2KCNH2
SCHEMBL20836159 0.76 GRM2 (0.79) GRM2KCNH2
SCHEMBL21123903 0.76 GRM2 (0.79) GRM2KCNH2
SCHEMBL21125003 0.75 GRM2 (0.77) GRM2KCNH2
SCHEMBL19632986 0.75 GRM2 (0.77) GRM2KCNH2
SCHEMBL19632993 0.74 GRM2 (0.51) GRM2KCNH2
SCHEMBL19633287 0.74 GRM2 (0.75) GRM2KCNH2
SCHEMBL20842366 0.73 GRM2 (0.86) GRM2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017198180-A1 FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF 中国科学院上海药物研究所 2017-11-23 WO disclosed